相关实验视频

Updated: Jul 9, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

周围血液中的VCAM-1水平升高与严重抑郁症中大脑结构和功能变化有关

Jingjing Zhou¹, Rui Liu¹, Jia Zhou¹

¹The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

Journal of affective disorders

|December 8, 2023

概括

重度抑郁症 (MDD) 患者表现出血管细胞粘附分子-1 (VCAM-1) 的水平升高. 这种分子与减少灰质体积和改变大脑连接性有关,这表明它在MDD病变发生过程中发挥了作用.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
精神病学是一个精神病学.

背景情况:

血管细胞粘附分子-1 (VCAM-1) 是内皮激活的关键标记物.
内皮功能障碍和炎症越来越多地与主要抑郁症 (MDD) 的病理生理学有关.

研究的目的:

在患有MDD的患者中检查周围VCAM-1水平.
探索VCAM-1,大脑结构 (灰质体积) 和MDD中的功能连接之间的关系.

主要方法:

招募了165名参与者 (85名MDD患者,80名健康对照).
使用ELISA测量了血清VCAM-1.
获得了133名参与者的磁共振成像 (MRI) 数据,以评估灰色物质体积 (GMV) 和功能连接 (FC).

主要成果:

与健康对照组相比,MDD患者的VCAM-1水平显著更高.
VCAM-1水平与GMV在右侧中间额叶皮质和后中心环中呈负相关性.
VCAM-1调解了组状况与后中环的GMV之间的关联,以及左腹前额皮层和右下叶之间的FC.

结论:

升高的VCAM-1与MDD中的结构和功能性大脑变化有关.
通过影响大脑结构和功能,VCAM-1可能在MDD的病因学中发挥作用.
研究结果表明VCAM-1是潜在的生物标志物,可以将免疫激活与抑郁症中的神经生物学变化联系起来.

关键词:

功能连接性的功能连接性.灰色物质体积,灰色物质体积.大型抑郁症主要是抑郁症.血管细胞粘附分子-1-1

更多相关视频

Animal Models of Depression - Chronic Despair Model CDM

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

相关概念视频

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...