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Updated: Jun 20, 2026

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定量系统毒理学建模在急性骨髓性白血病患者中对恩沃多斯塔特的安全剂量选择提供了信息

Kyunghee Yang1, Ronald Kong2, Robert Spiegel2

  • 1Quantitative Systems Pharmacology Solutions, Simulations Plus Inc., Research Triangle Park, North Carolina, USA.

Clinical pharmacology and therapeutics
|December 8, 2023
PubMed
概括

定量系统毒理模型预测了emvododstat在急性髓性白血病 (AML) 治疗中的肝脏安全性. 降低剂量在临床试验中证实了安全性,使AML治疗获得监管批准.

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