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相关概念视频

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

168
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
168
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

253
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
253
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

121
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
121
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

142
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
142
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

129
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
129

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克罗恩病:一个更新

Ella Cockburn1, Shahed Kamal2, Andrea Chan1

  • 1Royal Melbourne Hospital, Melbourne, Australia.

Clinical medicine (London, England)
|December 8, 2023
PubMed
概括

克罗恩病 (CD) 的管理重点是治疗和缓解症状. 治疗策略是根据个体患者的需要量身定制的,利用多种疗法,如氨酸和抗TNF药物,以获得更好的结果.

关键词:
克罗恩氏病 克罗恩氏病是什么?生物学是生物学的学科.炎症性肠病是一种炎症性肠病.

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科学领域:

  • 胃肠病学 胃肠病学
  • 免疫学 免疫学 免疫学
  • 临床医学 临床医学

背景情况:

  • 克罗恩氏病 (CD) 是一种慢性炎症性肠病 (IBD),其全球发病率越来越高.
  • 目前的管理目标是内镜治疗,症状缓解和改善生活质量.
  • 治疗方法多样化,并根据疾病表型指导.

研究的目的:

  • 审查当前克罗恩病的管理策略.
  • 突出不同CD表型中各种疗法的作用.
  • 强调CD中个性化治疗的趋势.

主要方法:

  • 对克罗恩病管理现有文献的综述.
  • 分析治疗选择,包括提奥普林,抗TNF药物和其他免疫抑制剂.
  • 讨论手术干预和个性化治疗方法.

主要成果:

  • 提奥普林是类固醇节约维持治疗的关键.
  • 抗瘤坏死因子 (抗TNF) 药物至关重要,特别是对于CD. fistulising.
  • 升级到其他疗法和手术可能是必要的低于最佳反应.

结论:

  • 根据患者表型,疾病严重程度和患者偏好量身定制治疗越来越可行.
  • 越来越多的治疗选择允许更个性化的克罗恩病管理.
  • 优化治疗策略对于改善CD患者的长期结果至关重要.