心肌梗塞后心脏交感性超内置:一个系统性审查和定性分析
H Sophia Chen1,2, Lieke van Roon2, Jan Schoones3
1Department of Cardiology, Center of Congenital Heart Disease Amsterdam Leiden (CAHAL), Leiden University Medical Center, Leiden, The Netherlands.
Annals of medicine
|December 8, 2023
概括
心肌梗塞 (MI) 后的心脏交感性超内内置与心脏突然死亡有关. 本综述澄清了其特征,时间和位置,突出了未来研究的研究差距.
科学领域:
- 心血管研究研究心血管研究
- 神经科学是一个神经科学.
- 病理生理学 病理生理学
背景情况:
- 心肌梗塞 (MI) 后的同情性心脏缩是已知的心律失常和突然心脏死亡的危险因素.
- 这种超内内流的确切特征,包括位置,数量和时间动态,仍然不完全理解.
研究的目的:
- 系统地审查和综合当前关于心肌梗塞后心脏交感性超内尔瓦的知识.
- 分析定义,实验模型,量化方法以及超内置的空间和时间模式.
- 为未来的研究方向确定现有文献中的空白.
主要方法:
- 进行了一次系统的文献搜索,以确定有关心脏交感性高内核发作后MI的相关研究.
- 包括的研究经历了全文审查和质量评估.
- 收集和定性分析了超内内化特征 (定义,模型,量化,位置,数量,时间) 的数据.
主要成果:
- 确定了在2000年至2022年间发表的60项符合条件的研究.
- 与对照人群相比,心脏内膜增大通常被定义为同情神经密度或数量的增加.
- 研究主要使用具有永久LAD结合的雄性大鼠;从MI后3天到3个多月,主要在边界区域观察到超内内化,报告量的显著变化可能是由于不同的量化方法.
结论:
- 在心脏病发作后,心脏交感性超内置主要发生在边界区域,在3天后出现并持续至少3个月.
- 这种情况最常被研究在男性大鼠中,这些大鼠接受了永久的LAD绑定.
- 报告的超内内化量显著变化需要进一步的研究,特别是专注于时间变化,慢性阶段,超神经部分,女性受试者和MI与再注射模型.
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