鼻内皮质类固醇可减少过敏鼻炎儿童的急性鼻炎:一项嵌套病例对照研究
Chia-Ling Lin1, Kuo-Huang Lee1, Wan-Ting Huang2
1Department of Pediatrics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 60002, Taiwan.
概括
鼻内皮质类固醇 (INCS) 与抗胰岛素相比,有效降低过敏鼻炎 (AR) 的儿童急性鼻炎风险. 适当的INCS治疗对于管理AR并发症和预防鼻炎至关重要.
科学领域:
- 儿科过敏和免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有过敏性鼻炎 (AR) 的儿童的急性鼻炎的发生率显著更高.
- 这项研究调查了常见的AR药物对儿科患者急性鼻炎发病率的影响.
研究的目的:
- 评估鼻内皮质类固醇 (INCS),第二代抗胰岛素 (SGH) 和/或鼻内抗胰岛素 (INH) 对AR儿童急性鼻炎的影响.
- 为了比较与不同药物治疗方案相关的风险,用于AR管理.
主要方法:
- 使用台湾国家卫生研究院数据库 (2005-2018) 进行了一项嵌套病例控制研究.
- 分析了接受AR药物治疗的2-18岁的AR患者队列.
- 进行了INCS,INH和/或SGH当前用户与远程/最近用户之间的比较,以及INCS (有/没有SGH) 和单独SGH之间的比较.
主要成果:
- 目前使用SGH和/或INCS的用户比远程用户更容易患急性鼻炎.
- 目前的SGH使用者比最近的使用者有更高的风险,但INCS使用者与最近的AR药物使用者相比没有差异.
- 与SGH单独治疗相比,当前的INCS使用,有或没有SGH,与急性鼻炎的风险较低有关.
结论:
- 结合INCS (有或没有SGH) 的治疗比单独使用SGH更有效地降低了急性鼻炎风险.
- 强调对过敏性鼻炎进行适当的INCS治疗的重要性,以减少儿童急性鼻炎的发生率.
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