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一种甘醇基托衍生物,具有额外纤维细胞去矿化潜力,可自蚀刻牙结合

Mingxing Li¹, Yuan Qiu¹, Yinlin Wang¹

¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.

Dental materials : official publication of the Academy of Dental Materials

|December 8, 2023

概括

一种新的牙科原料,糖醇基托-EDTA-甲酸盐 (GCE-MA),可以选择性地从牙原蛋白中去除矿物质. 这种外纤维脱矿剂的结合强度与商业系统相美.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
粘合式牙科粘合式牙科

背景情况:

外纤维化去矿化是一种牙蚀刻技术,可以保存内纤维化矿物质.
这种方法旨在防止用疏水性树脂单体取代水,增强粘合力.
目前的方法可能无法最佳地平衡去矿化和树脂透.

研究的目的:

为了合成和评估一种新的水溶性甘醇基托-EDTA-甲酸盐 (GCE-MA) 结合物.
评估GCE-MA作为一种外纤维细胞去矿物化剂的潜力,用于自我蚀刻牙结合.
为了研究试验原料的结合性能,MMP抑制和生物安全性.

主要方法:

甘醇基托桑与EDTA和甲基烯酸基基组功能化,由FTIR证实.
实验性的自我蚀刻原料是用GCE-MA结合剂制成的.
评估包括SEM/TEM去矿化,微拉伸键强度,MMP抑制试验,in-situ发烧镜,抗菌试验和细胞毒性试验.

主要成果:

确认了GCE-MA的成功合成和功能化.
GCE-MA有效地进行了牙原蛋白的外纤维脱矿化.
实验原料证明了微拉伸键强度与商业自蚀刻系统和酸蚀刻牙相提并论,抑制了MMP-9,并显示了最小的混合层光.

结论:

GCE-MA使牙矿物成分的选择性外纤维脱矿化成为可能.
含有GCE-MA的自蚀刻原料可以达到临床相关的结合强度.
这种新型结合剂在牙科应用中表现出有希望的抗菌和非细胞毒性质.

关键词:

牙粘合的粘合方式额外纤维细胞去矿化甘醇基托桑是一种酸盐.自己雕刻的雕刻

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