甲状腺状细胞癌中的免疫检查点抑制剂:系统性审查和元分析
Laura Pala1, Tommaso De Pas1, Erika Stucchi2
1Medical Oncology Unit, Humanitas Gavazzeni, Bergamo, Italy.
Seminars in oncology
|December 8, 2023
概括
免疫检查点抑制剂 (ICI) 在晚期甲状腺皮细胞癌 (SCCA) 中的疗效较低. 组合疗法可能为SCCA患者提供更好的结果,这需要进一步研究耐药机制.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道癌症 胃肠道癌症
背景情况:
- 门状细胞癌 (SCCA) 是一种罕见的恶性瘤.
- 虽然局部晚期疾病存在治疗选择,但转移性复发影响大约25%的患者.
- 化疗是高级SCCA的标准,对免疫疗法的新兴数据.
研究的目的:
- 评估免疫检查点抑制剂 (ICI) 在高级SCCA中的疗效.
- 确定ICI在这个患者群体中的整体反应率 (ORR) 和疾病控制率 (DCR).
主要方法:
- 一个系统的审查和潜在试验的元分析.
- 在PubMed,Embase和Scopus数据库中搜索到2022年12月31日.
- 包括六项前性试验 (七个治疗臂,347名患者),评估ICI作为单疗法或组合治疗.
主要成果:
- 在先进的SCCA中,ICI的综合整体反应率 (ORR) 为13% (95%CI,10-17%).
- 综合疾病控制率 (DCR) 为57% (95% CI,40%-74%).
- 除了组合疗法之外的敏感性分析并没有显著改变这些发现.
结论:
- 免疫检查点抑制剂作为高级SCCA的独立治疗方法的有效性有限.
- 涉及向药物或化疗的组合策略可能会改善治疗结果.
- 需要进一步的研究来阐明ICI耐药性机制,并优化治疗疗效.
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