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相关概念视频

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
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基于模型的深度学习框架用于加速光投射断层扫描.

Marcos Obando1, Andrea Bassi2, Nicolas Ducros3,4

  • 1Medical Physics Department, Centro Atómico Bariloche and Instituto Balseiro, 8400, Bariloche, Argentina.

Scientific reports
|December 8, 2023
PubMed
概括
此摘要是机器生成的。

我们开发了一种基于模型的深度学习算法,用于光投影断层扫描 (ToMoDL),可以显著减少成像和重建时间. 这种方法可以实现高质量的重建,与现有技术相提并论,即使训练数据有限.

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科学领域:

  • 生物医学成像学 生物医学成像学
  • 计算机成像成像技术
  • 深度学习应用程序深度学习应用程序

背景情况:

  • 光学投影断层扫描 (OPT) 对于3D生物成像至关重要.
  • 传统的OPT重建是耗时的.
  • 减少获取和重建时间对于高通量生物研究至关重要.

研究的目的:

  • 为加速光投影断层扫描 (ToMoDL) 引入一种基于模型的新型深度学习算法.
  • 为了减少OPT的收购和重建时间.
  • 为了比较ToMoDL的性能与已建立的重建方法.

主要方法:

  • 开发了一个基于模型的深度学习算法 (ToMoDL),通过卷积神经网络结合数据一致性和文物删除.
  • 包括一个预处理步骤,用于准确的样品对齐.
  • 在斑马鱼的发育阶段训练了算法,以最大限度地减少平均平方误差.
  • 通过对过的反向投影,压缩传感和直接深度学习方法进行交叉验证来验证.

主要成果:

  • ToMoDL实现了与现有方法相当或比现有方法更好的重建质量.
  • 对于高度低样本的数据集,ToMoDL和U-Net方法产生可比的图像.
  • 由于可训练参数较少,ToMoDL在有限的训练数据下表现出卓越的性能.

结论:

  • ToMoDL提供了显著的光投影断层扫描重建的加速.
  • 该方法很强大,在各种低样本场景中表现良好.
  • 在有限的培训数据集的情况下,ToMoDL特别有利,使其适合资源有限的研究.