多莫酸会影响大脑形态,并导致两种鱼类的行为变化
Kassandra Beltrán-Solís1, Ernesto García-Mendoza2, Samuel Sánchez-Serrano3
1Posgrado en Ecología Marina, Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California (CICESE), Ensenada, Mexico.
Scientific reports
|December 8, 2023
概括
口服暴露于多米酸 (DA) 在图阿巴和条纹鱼中会导致大脑和心脏损伤. 标准化测试显示了行为变化,表明鱼类对这种海洋毒素敏感.
科学领域:
- 海洋生物学 海洋生物学
- 神经毒理学 神经毒理学
- 生态毒理学 生态毒理学
背景情况:
- 多米酸 (DA) 是一种强大的海洋神经毒素,影响海鸟,海洋哺乳动物和人类.
- 鱼类通常被认为通过自然暴露途径对DA不那么敏感,与腹腔内给药不同.
- 之前的研究没有检测到天然DA暴露对鱼类的神经行为影响.
研究的目的:
- 为了研究口服摄入的DA对鱼类神经行为和组织病理学的影响.
- 为了确定生态相关的暴露途径是否会在鱼类中诱导DA毒性.
- 评估DA对托托阿巴和条纹鱼的慢性和急性影响.
主要方法:
- 托托阿巴和条纹鱼在7天内被食含有0.776μg DA g-1的饮食.
- 采用了标准化的行为测试 (黑暗/光明,避免反捕食者).
- 对大脑和心脏组织进行了组织病理学检查.
主要成果:
- 口服DA暴露导致了两种鱼类大脑 (视觉结膜,小脑) 和心脏的神经行为和组织病理变化.
- 观察到慢性影响,包括心脏病变和焦点心房忧郁症.
- 虽然激发性毒性迹象不存在,但使用标准化测试检测出行为障碍.
结论:
- 鱼类,特别是托托阿巴和条纹鱼,通过口服暴露容易受到DA神经毒性.
- 暴露于DA可以在鱼类中引起显著的病理和行为变化,从而产生潜在的生理和生态后果.
- 标准化行为测试对于检测暴露于海洋毒素的鱼类中微妙的神经毒性影响至关重要.
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