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产后类固醇作为肺部保护和抗炎药在早产羔羊暴露于产前炎症
Paris C Papagianis1, Peter B Noble2, Siavash Ahmadi-Noorbakhsh2
1Department of Pharmacology, School of Medicine, Nursing and Health Sciences, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. paris.papagianis@monash.edu.
产后低剂量德克萨米他并没有降低患有产前炎症的早产羔羊的呼吸器需求. 然而,它确实降低了肺炎和病态加厚,这表明它对早产肺部发育有潜在的益处.
科学领域:
- 新生儿科学 新生儿科学
- 肺部病理学 肺部病理学
- 发展生物学 发展生物学
背景情况:
- 在早产婴儿中,产前炎症和膜化受损会先发 bronchopulmonary dysplasia (BPD).
- 葡萄糖皮质类药物减少了对呼吸器的需求,但高剂量会抑制气泡化.
- 葡萄糖皮质激素在产前炎症后对肺部发育的影响尚不清楚.
研究的目的:
- 为了调查产后低剂量德克萨米他是否减少呼吸器需求,炎症和BPD类肺病理在早产羊羔与产前炎症.
主要方法:
- 怀孕的母羊接受了内LPS或盐水;早产的羔羊是在48小时后分娩的.
- 羊羔被随机分配,从出生后3小时内开始接受静脉注射的甲或盐水.
- 呼吸系统的支持降低了,并在第7天收集了肺组织.
主要成果:
- 呼吸支需求在各组之间没有显著差异.
- 与对照组相比,用德甲治疗的羊羔显示肺炎的标志物减少.
- 组织学分析显示,在患有产前炎症的羊群中,组织含量较高,但肺气泡化不变.
结论:
- 缩低剂量德克萨梅他可减少肺炎和病理性肺厚化在早产羔羊暴露于产前炎症.
- 虽然没有减少呼吸器需求,但德克萨米他对早产肺部表现出有益的成熟作用.
- 对适当的逐渐缩小的产后德克萨米他剂量进行进一步的探索是有必要的,用于输出依赖氧气的新生儿.
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