超重/肥胖儿童的早期生活因素和结构性大脑网络:ActiveBrains项目
Patricio Solis-Urra1,2,3, Maria Rodriguez-Ayllon4, Juan Verdejo-Román5,6
1Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. patriciosolis@ugr.es.
Pediatric research
|December 8, 2023
概括
出生的体重和长度与超重/肥胖儿童的大脑结构有关,但不是母乳养. 这些早期生活因素并没有影响研究小组的学业成绩.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 公共卫生 公共卫生
背景情况:
- 研究早期生活因素对大脑发育的影响对于了解儿童健康至关重要.
- 儿童的超重/肥胖 (OW/OB) 可能会影响神经发育轨迹.
- 了解OW/OB儿童早期生活因素,大脑结构和学业表现之间的联系很重要.
研究的目的:
- 检查早期生活因素 (出生体重,出生长度,母乳养) 与OW/OB.儿童的结构性大脑网络之间的关联.
- 确定受早期生活因素影响的结构性大脑网络是否与这一群体的学业表现相关.
主要方法:
- 利用来自ActiveBrains项目的96名儿童 (8-11岁) 的OW/OB的T1加权MRI图像.
- 采用非负矩阵分解 (NNMF) 来识别结构性大脑网络.
- 通过出生记录和家长报告收集早期生活数据 (出生体重,长度,母乳养时间);使用伍德考克-穆诺兹标准化测试电池评估学业表现.
主要成果:
- 出生体重和出生长度与七个结构性大脑网络有显著的关联,包括小脑,环状回环,尾极和关键的皮下区域 (海马,尾状核,面,皮,核,杏仁体).
- 在母乳养实践和结构性大脑网络之间没有发现显著的关联.
- 与出生体重或长度相关的已识别的大脑网络中,没有一个与研究儿童的学业成绩有相关性.
结论:
- 出生体重和出生长度与OW/OB儿童的特定结构性大脑网络有关,这表明它们在正常大脑发育中起作用.
- 在这个人群中,没有发现母乳养与这些大脑网络有关.
- 虽然早期生活因素影响大脑结构,但这项研究没有发现与学业表现的直接联系,因此需要进一步调查其他潜在的行为结果.
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