对治疗骨和关节感染的菌体疗法的审查
Tristan Ferry1,2,3,4,5
1Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. tristan.ferry@univ-lyon1.fr.
Methods in molecular biology (Clifton, N.J.)
|December 8, 2023
概括
菌体疗法对骨关节感染 (BJIs) 有希望,特别是假肢关节感染,当选择保守的管理时. 在BJIs中用于菌体治疗的最佳施用策略需要进一步研究.
科学领域:
- 细菌学 细菌学是一门学科.
- 传染性疾病 传染性疾病
- 整形外科手术 整形外科手术
背景情况:
- 骨关节感染 (BJIs) 存在复杂的管理挑战,通常需要手术和抗生素.
- 菌体 (菌体) 在体外表现出对BJI相关的细菌病原体和生物膜的活性.
- 菌体治疗BJIs的临床应用正在出现,需要研究最佳的管理和患者选择.
研究的目的:
- 探索菌体治疗在治疗骨关节感染 (BJIs) 的理由和潜在应用.
- 确定可能受益于菌体治疗的相关BJI类型和患者群体.
- 突出现代医学和骨科手术中新兴的菌体疗法2.0时代.
主要方法:
- 对菌体对细菌病原体和与BJIs相关的生物膜活性现有文献的审查.
- 分析BJIs的临床形式和当前的治疗模式.
- 讨论BJIs中菌体治疗的潜在指示和禁忌.
主要成果:
- 菌体在体外表现出对BJIs涉及的细菌病原体和生物膜的活性.
- 假肢关节感染,保守地管理,似乎是菌体治疗的相关指示.
- 暴露骨的BJIs,除了糖尿病足部感染,可能不适合菌体治疗.
结论:
- 菌体疗法或细菌体疗法正在进入一个新的时代,有可能在骨科手术中进行个性化治疗.
- 需要进一步的研究,以建立最佳的菌体给药方法BJIs.
- 非传统抗菌疗法 (ESGNTA) 的ESCMID研究小组正在推动菌体治疗领域的发展.
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