综合的泛癌分析显示,CCDC58是与免疫透相关的致癌因素
Huili Wu1, Qing Geng2, Wenxiang Shi3
1Department of Endodontics, Zhonglou Hospital, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.
Apoptosis : an international journal on programmed cell death
|December 8, 2023
概括
在许多癌症中,CCDC58基因被上调,并与预后不佳有关. 它还影响免疫反应和药物敏感性,显示作为泛癌生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 生物信息学是一种生物信息学.
背景情况:
- CCDC58蛋白家族在肝细胞癌 (HCC) 和乳腺癌中的参与.
- 在其他瘤类型中对CCDC58的研究有限.
- 需要对CCDC58.8的胰腺癌评估.
研究的目的:
- 评估CCDC58在胰腺癌中的重要性.
- 评估CCDC58在瘤进展,预后和免疫反应中的作用.
主要方法:
- 使用的TCGA,GTEx,UALCAN,cBioPortal,SMART,STRING,GEPIA2,CancerSEA,ESTIMATE,TIMER2.0,TISIDB,TIDE,TIMSO,TCIA数据库.这些数据库中包含的数据库包括:
- 进行了差异表达,预后,突变,甲基化,基因相互作用,丰富,单细胞,免疫透和药物敏感性分析.
主要成果:
- 在多种瘤类型中,CCDC58的升高调节,与预后不佳相关.
- 在25个瘤中,CCDC58突变增加;表达与甲基化有负相关性.
- CCDC58与免疫/风脉得分和特定免疫细胞负相关;与瘤异质性,干性,DNA甲基转移酶和MMR基因正相关.
结论:
- CCDC58是一个重要的泛癌预后标志物和免疫反应指标.
- CCDC58显示了HCC作为一个独立的风险因素和预测药物敏感性的潜力.
- 综合分析强调了CCDC58在胰腺癌研究中的临床价值和影响.
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