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不同HPV基因型和年龄的患者的直接组织学相关性:中国单一中心分析

Linghua Kong¹, Xiaoping Xiao¹, Tao Xu²

¹Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, National Clinical Research Center for Obstetric & Gynecologic Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

|December 9, 2023

概括

人类乳头瘤病毒 (HPV) 基因型,特别是HPV16,与高度的宫内皮质瘤 (CIN) 密切相关. 25至44岁的妇女患CIN3的发病率最高,这凸显了针对性查的必要性.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
病毒学病毒学

背景情况:

人类乳头瘤病毒 (HPV) 是导致宫癌,宫内皮质瘤 (CIN) 和宫细胞恶性转变的主要原因.
了解特定HPV基因型,患者年龄和组织学宫病变之间的关联对于有效的查和预防策略至关重要.

研究的目的:

调查不同人类乳头瘤病毒 (HPV) 基因型和患有立即组织病变的患者年龄之间的关系.
分析不同严重程度的单型HPV基因型在CIN中的分布,以及单型HPV感染的年龄相关流行率.

主要方法:

从单一妇科诊所 (2017年10月 - 2020年5月) 分析了1661个样本,其组织学发现通过活检得到证实.
检查CIN不同级别内的单型HPV基因型的分布.
对单一型HPV感染的年龄特定流行率的评估.

主要成果:

在CIN2和CIN3中,HPV16,58,52,33和31/18是最常见的高风险HPV (hrHPV) 类型,占单一HPV感染的88%以上.
在CIN2 (46.24%) 和CIN3 (55.21%) 中,HPV16是主要的基因型,近三分之一的HPV16阳性患者患有高度CIN.
CIN3的高峰发病率发生在25-34岁 (33.68%) 和35-44岁 (31.58%) 的女性中. 在CIN2或CIN3病例中没有检测到HPV45.

结论:

高度CIN在25至44岁的女性中达到顶峰,建议针对这一人口群进行查.
具有HPV16阳性的个体需要优先查;HPV45似乎与CIN2/3.3的关联性很低.
一种包含常见基因型 (HPV16,58,52,33,31,18) 的潜在HPV疫苗可以显著帮助中国的宫癌预防.

关键词:

年龄年龄年龄年龄年龄年龄宫内皮质瘤 (CIN) 是一种宫内皮质瘤.基因型分布的分布人类乳头瘤病毒 (HPV)

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