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纳米凝与共价结合和可释放的三糖用于动脉样硬化中的自刺激

Yuan Zhong¹, Ali Maruf^2,3, Kai Qu¹

¹Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Faculty of Medicine, Chongqing University, Chongqing, 400030, China.

Journal of nanobiotechnology

|December 9, 2023

概括

三醇纳米凝 (TNG) 改善动脉样硬化中的自和脂质去除. 这种新型的输送系统减少了小鼠的动脉斑块积累,为血管疾病提供了有前途的治疗方法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
心血管研究研究心血管研究

背景情况:

动脉样硬化涉及自和脂质在泡细胞中的积累受损,有助于血管疾病.
三糖是一种自诱导剂,由于其水友性质,其生物可用性较差.
恢复自功能是缓解动脉样硬化进展的关键.

研究的目的:

开发和评估三释放纳米凝 (TNG) 以提高在动脉样硬化中的生物可用性和治疗疗效.
调查TNG刺激自和促进泡细胞中的脂质排放的能力.
评估TNG对动脉样硬化斑块减少的体内影响.

主要方法:

通过对6-O-烯-三醇与烯胺类单体的共聚合制造TNG.
关于TNG大小 (67 nm),形状,泽塔电位 (-18 mV) 和体稳定性的特征.
在体外评估TNG诱导的泡细胞中的自和脂质流动.
在ApoE-/-小鼠体内评估TNG以测量动脉样硬化斑块负担和自标志物.

主要成果:

转化天然气表现出高三糖含量 (~58% w/w),在生物介质中具有良好的稳定性和非溶血性质.
实验室研究证实TNG刺激了泡细胞中的自和增强脂质流量.
在ApoE-/-小鼠的体内研究表明,动脉样硬化斑块显著减少,自标志物增加.

结论:

三醇纳米凝 (TNG) 是一个有前途的输送系统,可以提高三醇的生物可用性.
TNG有效地恢复受损的自介导脂质排放,这对于治疗动脉样硬化至关重要.
TNG在减少动脉样硬化斑块和管理血管疾病方面显示出显著的潜力.

关键词:

动脉样硬化是一种动脉样硬化.自自是一种自的过程.药物输送是药物输送的过程.纳米凝是一种纳米凝.这种树脂含有三糖.

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