慢性鼻炎与鼻息肉患者的生物使用和治疗模式:美国现实研究
Jared Silver1, Elizabeth Packnett2, Julie Park2
1GSK, Durham, NC, USA.
概括
慢性鼻炎与鼻息肉 (CRSwNP) 的生物学使用与特定的患者因素有关,并且通常在鼻手术之前进行. 了解这些预测因素可以优化CRSwNP患者的治疗策略.
科学领域:
- 耳鼻喉科和肺部病学中的现实世界的证据.
- 药物经济学和治疗模式分析.
- 先进治疗利用的临床预测因素.
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种严重的疾病,在美国有几种生物治疗选择.
- 了解现实世界的治疗模式对于优化患者护理和资源配置至关重要.
- 本研究探讨了影响在CRSwNP管理中采用生物疗法的因素.
研究的目的:
- 在现实环境中描述CRSwNP的当前治疗模式.
- 确定预测生物药物的使用的患者特异性因素.
- 为临床实践提供有关在CRSwNP中适当使用生物制剂的信息.
主要方法:
- 一项使用美国Merative MarketScan数据库 (2018年6月至2020年6月) 的回顾性,横截面研究.
- 纳入标准:成年人对CRSwNP.有医疗索赔.
- 根据鼻手术状态和生物用途分层的数据分析,检查患者的特征和治疗模式.
主要成果:
- 在5997名CRSwNP患者中,有10.7%使用了生物药物;这些使用者患病率较高,尤其是喘 (89.1%对35.0%).
- 生物使用在鼻手术前或后不久更为频繁 (11.6%的术后用户).
- 生物使用的预测因素包括并发症 (特别是喘,几率比5.46),先前口服皮质类固醇/多西环素使用,65岁以下的年龄.
结论:
- 在CRSwNP中,生物治疗的启动往往发生在鼻手术之前或在鼻手术期间.
- 患有较高未满足需求的患者,根据并发症和先前的治疗方法表明,更有可能接受生物药物.
- 已识别的预测因素可以指导临床决策对生物治疗在CRSwNP.
更多相关视频
相关概念视频
01:17Drugs Used in Lower Respiratory Disorders: Overview
450
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
450
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
266
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
266
01:26COPD: Management Using Bronchodilators and Corticosteroids
213
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
213
01:16Drugs Used in Upper Respiratory Disorders: Overview
256
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
256
01:30Epistaxis
166
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
166