后COVID运动不耐受与毛细血管变化和骨肌肉免疫失调有关
Tom Aschman1, Emanuel Wyler2, Oliver Baum3
1Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. tom.aschman@charite.de.
Acta neuropathologica communications
|December 9, 2023
概括
长期COVID患者表现出骨肌肉微血管变化,包括毛细血管减少和巨细胞增加,这可能解释了SARS-CoV-2感染后的持续疲劳.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 病毒学 病毒学
背景情况:
- SARS-CoV-2 流行病导致了广泛的急性感染和持续的后传染性综合征,称为长期COVID.
- 由于症状异质性和组织样本有限,了解长期COVID的机制具有挑战性.
研究的目的:
- 调查SARS-CoV-2感染后患者持续疲劳和劳动后不适的潜在机制.
- 分析骨肌肉活检以检测结构和免疫学变化.
主要方法:
- 从长期COVID患者的11个骨肌肉活检的深入分析持续疲劳.
- 与两个独立的历史控制队伍进行比较.
- 对肌肉组织进行SARS-CoV-2RNA和血清对补充系统蛋白质的分析.
主要成果:
- 患者在骨肌肉中表现出较少的毛细血管和更厚的毛细血管底层膜.
- 在肌肉组织中观察到CD169阳性巨细胞的数量增加.
- 在肌肉中没有检测到SARS-CoV-2RNA;然而,在血清和肌肉组织中发现了补充系统蛋白质的升高.
结论:
- 这些发现表明,在SARS-CoV-2感染后,微血管结构发生了免疫媒介的结构变化.
- 这些微血管变化可能解释了长期COVID的运动依赖性疲劳和肌肉疼痛.
- 需要进一步研究免疫反应和血管病理.
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