在英国生物银行中,行为摄影测量睡眠时间,连续性和时间与死亡率之间的联系
Pedro F Saint-Maurice1,2, Joshua R Freeman1, Daniel Russ1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sleep
|December 9, 2023
概括
睡眠时间较短和睡眠时间不规则会增加死亡风险. 促进健康的睡眠模式对于公共健康和寿命至关重要.
科学领域:
- 睡眠科学 睡眠科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 睡眠是影响整体健康的基本生物过程.
- 了解睡眠特征与死亡率之间的关系对于预防性健康策略至关重要.
- 之前的研究已经表明了睡眠与死亡之间的联系,但客观的措施,如动图,提供更精确的数据.
研究的目的:
- 调查睡眠时间,连续性和时间的客观测量与所有原因,癌症和心血管疾病 (CVD) 死亡率之间的关联.
- 利用来自大型队列的动图数据,提供睡眠死亡率关联的可靠估计.
主要方法:
- 利用了英国生物库的88,282名成年人 (40-69岁) 的数据,他们戴着手腕加速度计7天.
- 经过动图数据的处理,得出了睡眠时间,睡眠开始后醒来 (WASO),醒来次数,以及最不活跃的5小时 (L5) 的中点.
- 考克斯的比例危险模型被用来评估与死亡结果的关联,并对共变量进行调整.
主要成果:
- 较短的睡眠时间 (例如,每天5小时) 与与每天7小时相比,增加29%的全因死亡风险有关.
- 最不活跃5小时 (L5) 的早期 (凌晨2:30分以下) 或晚期 (凌晨3:30分以上) 中点与所有死因死亡风险增加20%左右有关.
- 睡眠开始后醒来 (WASO) 和醒来次数与死亡风险没有显著关联.
结论:
- 较短的睡眠时间和非最佳的睡眠时间 (早或晚) 是增加全因,癌症和心血管疾病死亡率的重要风险因素.
- 通过行为摄影对睡眠的客观测量证实了睡眠时间和时间不足对死亡率的有害影响.
- 这些发现强调了旨在改善成年人睡眠时间和时间的公共卫生倡议的重要性.
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