在IPF中,Voxel-Wise对同步注册的定量CT和高极化气体扩散权重MRI测量的比较
Ho-Fung Chan1, Nicholas D Weatherley1,2, Alberto M Biancardi1
1POLARIS, Imaging Section, Division of Clinical Medicine, University of Sheffield, Sheffield S10 2JF, UK.
Diagnostics (Basel, Switzerland)
|December 9, 2023
概括
超极化气体扩散加权MRI检测异常性肺纤维化 (IPF) 中的微观结构性肺部变化,这些变化在CT扫描上是看不见的. 这种成像技术可以揭示常规定量CT分析遗漏的早期疾病模式.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 异形性肺纤维化 (IPF) 是一种进展性肺病,其扩散权重 (DW) MRI 模式未知.
- 定量CT分析,如CALIPER,用于评估IPF,但其与高级MRI的相关性尚不清楚.
研究的目的:
- 开发一个空间联合注册框架,用于比较高极化气体DW-MRI和CALIPER定量CT模式在IPF.
- 为了研究DW-MRI指标和CT定义的疾病模式之间的voxel-wise关系.
主要方法:
- 在16名IPF患者和6名健康志愿者中开发了3He DW-MRI和定量CT的联合注册框架.
- 对显微扩散系数 (ADC) 和平均面维度 (LmD) 地图与基线和1年随访时的CALIPER CT模式进行了对象比较.
- 使用布兰德-阿尔特曼分析来比较从LmD和CALIPER获得的异常肺部百分比.
主要成果:
- 最大的DW-MRI指标与CT上的蜂区域相关.
- 在有网状变化和地面玻璃不透明的区域观察到纵向DW-MRI变化.
- 在DW-MRI检测到CT上看起来正常的肺部区域的微观结构变化,对于异常的肺部百分比,CALIPER的平均偏差为-15.3%.
结论:
- 超极化气体DW-MRI显示了检测IPF微观微观结构性肺部变化的潜力.
- 这种技术可以识别标准CT分析遗漏的早期疾病模式.
- 开发的共同注册框架允许直接比较IPF中先进的MRI和定量CT发现.
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