在复发性淋巴瘤中选择双特定抗体疗法或CAR-T细胞疗法
1Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Hematology. American Society of Hematology. Education Program
|December 9, 2023
概括
化学抗原受体T细胞 (CAR-T) 和双特异单克隆抗体 (BsAb) 疗法为侵袭性B细胞非霍奇金淋巴瘤提供了新的希望. 本综述将这些治疗方法进行比较,以指导测序决策,以获得更好的患者结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 复发性和耐火性 (R/R) 攻击性B细胞非霍奇金淋巴瘤 (NHL) 在历史上有不良预后.
- 化学抗原受体T细胞 (CAR-T) 疗法已经成为这些患者的一个子集的潜在治疗选择.
- 新型双特异单克隆抗体 (BsAb) 疗法也在R/R攻击性大B细胞淋巴瘤 (LBCL) 中表现出显著的活性.
结论:
- CAR-T和BsAb疗法的出现已经改变了R/R LBCL的治疗格局.
- 对这些疗法进行测序的战略方法对于最大限度地使患者受益至关重要.
- 进一步的研究和临床经验将继续完善最佳治疗途径.
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
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