肝脏中的"小肝细胞"
Toshihiro Mitaka1, Norihisa Ichinohe1, Naoki Tanimizu1,2
1Department of Tissue Development and Regeneration, Institute of Regenerative Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Cells
|December 9, 2023
概括
小肝细胞 (SHs) 是对肝脏再生至关重要的原始细胞. 这些细胞来自成熟的肝细胞 (MHs),在肝损伤后出现,并有助于肝脏的修复,突出显示它们的再生潜力.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 细胞生物学 细胞生物学
- 再生医学是一种再生医学.
背景情况:
- 成年动物的肝脏含有成熟的肝细胞 (MHs),具有不同的繁殖能力:MH-I (原始细胞),MH-II (有限的分裂) 和MH-III (衰老).
- 在大鼠肝细胞培养物中发现了形态相似但比MH小的小肝细胞 (SHs),并被认为是来自MH-I的肝细胞原始体.
研究的目的:
- 审查小肝细胞 (SHs) 在肝脏再生中的出现和重要性.
- 探索SHs在肝损伤和修复的背景下的起源和作用.
主要方法:
- 文献综述侧重于小肝细胞 (SHs) 在肝脏再生中的研究.
- 对肝细胞亚群及其在肝脏发育和损伤中的作用进行现有研究的分析.
主要成果:
- 小型肝细胞 (SHs) 被确定为损伤后肝脏再生的关键参与者.
- 受伤肝脏中的SHs来自成熟肝细胞 (MHs) 和肝脏干细胞.
- 由MH衍生的SHs的患病率取决于残留的MHs在受伤后的增殖能力.
结论:
- 小型肝细胞 (SHs) 对于肝脏再生至关重要,充当补充成熟肝细胞的原始细胞.
- 了解SHs的双重起源对于理解肝脏修复机制至关重要.
- SHs代表了促进肝脏疾病再生医学策略的重要研究领域.
相关概念视频
Liver Histology
807
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
807
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Gross Anatomy of the Liver
447
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
447
Liver Physiology
567
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
567


