艾弗·易斯食道切除术后的生活质量和与消化功能不良相关的独立因素
Valerian Dirr1, Diana Vetter1, Thomas Sartoretti2
1Department of Visceral and Transplant Surgery, University Hospital Zürich, 8032 Zürich, Switzerland.
Cancers
|December 9, 2023
概括
艾佛·易斯食道切除术显著损害消化功能和生活质量. 诸如并发症和手术方法等因素增加了癌症患者不良结果的风险.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 消化系统生理学 消化系统生理学
背景情况:
- 胸腔外食道切除术,特别是艾弗·易斯手术,极大地改变了前肠解剖学.
- 这些解剖学变化对消化系统生理学和患者福祉有着深刻的影响.
研究的目的:
- 为了识别因子,与功能性结果降低Ivor Lewis食道切除术后.
- 评估消化功能和与健康相关的生活质量 (HRQL) 的多个维度.
主要方法:
- 包括Ivor Lewis食道切除术后没有癌症的生存患者.
- 评估四种功能性综合征:消化不良,胃食道逆流病 (GERD),胃管排空延迟 (DGCE) 和倾倒综合征 (DS),以及HRQL使用问卷.
- 多变量分析以确定与消化性能差相关的独立因素,将结果与健康对照进行比较.
主要成果:
- 与对照组相比,手术后的患者报告说,与对照组相比,食障碍,GERD,DS和HRQL的结果更差;DGCE没有显著差异.
- 多变量分析显示了消化能力下降和ASA得分更高,状细胞癌,开放或混合手术方法和 (新) 辅助疗法之间的相关性.
- 没有单一的患者因素被确定与倾销综合征有关.
结论:
- 艾沃尔·易斯食道切除术导致癌症患者的消化功能和HRQL显著受损.
- 患有并发症的患者,接受多式治疗和接受状细胞癌的开放式手术,面临着较差功能结果的最高风险.
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