相关实验视频

Updated: Jul 9, 2025

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

对肝细胞癌移植后复发的治疗方法:确定性和未解决的问题

Giuseppe Marrone¹, Maria Sandrina Leone¹, Marco Biolato¹

¹Medical and Surgical Sciences Department, Policlinico Universitario A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

|December 9, 2023

概括

在肝移植 (LT) 后治疗肝细胞癌 (HCC) 复发是复杂的. 本综述探讨了关于移植后HCC管理的当前文献,解决了治疗策略中的证据和争议.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 是肝移植 (LT) 的原因越来越多.
有效的LT前候选人选择对于尽量减少LT后复发至关重要.
功能性肝功能障碍和移植中心协议的异质性复杂化了LT前治疗决策.

研究的目的:

审查当前关于管理LT后HCC复发的文献.
讨论有关移植后HCC治疗策略的证据和争议.
突出患者管理方面的挑战,包括免疫抑制和药物相互作用.

主要方法:

对最近关于移植后HCC复发的研究进行文献综述.
对治疗策略的分析,包括桥梁和降级治疗.
检查影响治疗决策的因素,如肝功能和免疫抑制.

主要成果:

没有普遍接受的指导方针用于治疗LT后的复发性HCC.
在理论上,LT后改善的肝功能允许更多的治疗选择.
重要挑战包括管理免疫抑制,药物毒性和药物相互作用.

结论:

移植后HCC复发的管理需要仔细考虑个体患者的因素.
由于排斥风险,关于使用较新的免疫疗法存在争议.
需要进行进一步的研究,以制定明确的指导方针,用于LT后的HCC复发治疗.

关键词:

HCC的复发情况检查点抑制剂检查点抑制剂肝移植肝移植肝移植这是一种mTOR抑制剂.这是一种血管侵袭.

更多相关视频

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

相关概念视频

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.