相关实验视频
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在中国食道状细胞癌的危险因素概述
Erica Conway1, Haisheng Wu1, Linwei Tian1
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China.
Cancers
|December 9, 2023
概括
中国的食道状细胞癌 (ESCC) 与遗传学,饮食,HPV和生活方式有关. 包括遗传查和公共卫生教育在内的综合战略对于高风险地区的预防至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 中国的食道状细胞癌 (ESCC) 发病率是世界上最高的,在某些地区超过每10万人的100%.
- 尽管有重大公共卫生举措,但中国的ESCC的确切原因仍然不完全理解.
研究的目的:
- 系统地审查和综合现有关于中国食道状细胞癌 (ESCC) 的潜在病因因素的现有研究.
- 巩固对中国人口中ESCC病因学的遗传,饮食,传染性和其他环境影响的发现.
主要方法:
- 在四个主要数据库中使用相关关键字进行了系统的文献搜索.
- 研究使用Rayyan软件进行了选和审查,数据被提取并汇总到Excel表中进行分析.
主要成果:
- 该审查包括207项研究,主要关注遗传因素 (129项研究).
- 饮食因素 (22项研究),人类乳头瘤病毒 (HPV) 感染 (19项研究) 和其他各种因素 (37项研究) 也被调查.
结论:
- 中国的食道状细胞癌 (ESCC) 是多因素的,涉及遗传倾向,基因环境相互作用,饮食习惯 (酒精,烟草,制食品,热食品/饮料),HPV感染,口腔健康不佳和社会经济地位.
- 有效的公共卫生战略必须整合遗传查,环境和生活方式影响的彻底调查,加强口腔健康教育,并考虑社会经济决定因素,以减轻高风险中国人群中的ESCC.
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