乳腺癌治疗:针对目标还是不针对目标? 这就是问题
Alexandra Stone1,2, Kevin M Lin1,2, Ghanshyam H Ghelani3,4
1Department of Urology, SUNY Upstate Medical University, 750 East Adams Str., Syracuse, NY 13010, USA.
Cancers
|December 9, 2023
概括
雄激素受体 (AR) 组合疗法在治疗三阴性乳腺癌 (TNBC) 中表现有前途. 分析临床益处率 (CBR) 对于推进TNBC治疗选择至关重要.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 三阴性乳腺癌 (TNBC) 缺乏有效的向疗法.
- 雄激素受体 (AR) 已经显示出作为TNBC治疗点的潜力,但作为唯一的点,它取得了有限的成功.
研究的目的:
- 通过分析临床试验,评估AR在TNBC治疗中的作用.
- 调查针对AR与其他信号分子的组合疗法的疗效.
主要方法:
- 对针对AR或共同针对AR的现有和已完成的临床试验的分析.
- 确定与AR抑制剂联合治疗中使用的流行生物标志物,包括CDK4/6,CYP17溶解酶和PI3K/AKT通路.
主要成果:
- 结合疗法涉及AR抑制剂和其他生物标志物,如CDK4/6,CYP17酶和PI3K/AKT通路组件,在TNBC临床试验中经常被探索.
- 以前试图使用AR作为TNBC全身治疗的单剂点的尝试在很大程度上没有成功.
结论:
- 针对AR与其他信号分子结合,代表了改善TNBC治疗的有希望的策略.
- 在组合治疗试验中分析临床益处率 (CBR) 对于推进TNBC治疗选择和患者预后至关重要.
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