固体脂质纳米颗粒含有多巴胺和葡萄提取物:冷干燥与冷保护作为一种配方策略,以实现鼻子粉末
Elvira De Giglio1, Udo Bakowsky2, Konrad Engelhardt2
1Department of Chemistry, University of Bari "Aldo Moro", 70125 Bari, Italy.
Molecules (Basel, Switzerland)
|December 9, 2023
概括
糖有效地冷保护固体脂质纳米颗粒 (SLN) 用于鼻腔输送多巴胺和葡萄提取物,显示出对帕金森病治疗的希望.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 封装多巴胺 (DA) 和葡萄提取物 (GSE) 的固体脂质纳米粒子 (SLNs) 已被开发用于潜在的帕金森病 (PD) 治疗.
- 该研究的重点是创建这些SLN的粉末配方,用于鼻腔注射.
研究的目的:
- 评估糖和甲基-β-环氧化 (Me-β-CD) 作为DA和GSE载体SLN的冷保护剂.
- 评估冷保护的SLN粉末的物理化学特性和体外性能.
主要方法:
- 使用融同质化方法制备SLN.
- 物理化学表征包括拉曼光谱,SEM,AFM和XPS.
- 实验室释放研究在模拟鼻液和细胞活力测试中进行.
主要成果:
- 与Me-β-CD相比,糖为SLN提供了优越的冷保护和物理稳定性.
- 从冷保护的SLN中观察到多巴胺释放,而GSE释放是最小的.
- 与SLN-Me-β-CD不同,SLN-糖配方显示出良好的细胞活力.
结论:
- 糖是冷保护DA/GSE装载SLN的一个有前途的辅助剂.
- 这导致了一种稳定的粉末鼻腔剂型,适合帕金森病患者.
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