作为抗病毒剂的精选植物三烯酸及其衍生物
Martina Wimmerová1,2, Uladzimir Bildziukevich2, Zdeněk Wimmer1,2
1Department of Chemistry of Natural Compounds, University of Chemistry and Technology in Prague, Technická 5, 16028 Prague, Czech Republic.
Molecules (Basel, Switzerland)
|December 9, 2023
概括
本综述总结了针对HIV-1和HSV-1的三类抗病毒药物. 贝图林酸衍生物,如贝维里马特,是关键,在临床试验结束后推动新化合物的研究.
科学领域:
- 药用化学 医学化学
- 病毒学 病毒学
- 自然产品 化学 化学
背景情况:
- 三聚类化合物已经显示出作为抗病毒剂的前景.
- 研究重点是贝图林和贝图林酸的衍生物,特别是贝维里马特.
- 结束了bevirimat的临床试验,刺激了新的抗病毒候选药物的开发.
研究的目的:
- 审查和总结最近对基于三基的抗病毒药物的研究.
- 突出抗病毒研究的历史成就和连续性.
- 分析新型抗病毒化合物的结构基础和发展趋势.
主要方法:
- 关于三类抗病毒药物的科学研究的文献综述.
- 分析来自贝林,贝林酸和其他三类化合物的化合物.
- 根据它们的三基核结构对审查的药物进行分类.
主要成果:
- 贝维里马特 (Bevirimat) 是贝鲁林酸的合成衍生物,一直是重要的焦点.
- 大多数新的抗病毒候选药物都是贝鲁林酸衍生物,较少的衍生物来自其他三烯酸.
- 寻找新型抗病毒药物的研究主要集中在酸支架周围.
结论:
- 贝图林酸衍生物在寻找新型抗病毒药物的过程中占据主导地位.
- 替代的三基基架在抗病毒药物开发方面尚未得到充分探索.
- 未来的研究可能会从探索更广泛的三类结构来治疗HIV-1和HSV-1中获益.
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