生物活性化物作为来自植物内生菌的二次代谢物 Aspergillus 属 属
Juntai Zhu1,2, Lixia Song1, Shengnan Shen1,3
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Molecules (Basel, Switzerland)
|December 9, 2023
概括
内生性阿斯伯吉洛菌产生各种各样的生物活性化物. 本综述详细介绍了263种来自阿斯伯吉卢的化物,强调了它们的结构多样性和对各种疾病的治疗潜力.
科学领域:
- 自然产品化学 自然产品化学
- 微生物生物技术 微生物生物技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 类化合物是一种重要的自然产品类别,具有广泛的临床应用.
- 内生真菌,特别是阿斯伯吉勒斯菌种,是生物活性二次代谢产物的丰富来源.
- 这次审查是第一个全面检查来自内性阿斯伯吉卢斯菌的类化合物的综合性审查.
研究的目的:
- 审查和分类由内性Aspergillus.gillus产生的化物.
- 详细介绍这些化合物的结构多样性和生物活性.
- 突出阿斯伯吉勒斯衍生类化合物的治疗和经济重要性.
主要方法:
- 广泛的文献审查和数据分析.
- 基于结构特征的类化合物的分类.
- 报告生物活动的汇编.
主要成果:
- 鉴定和分类了263种来自内性阿斯伯吉卢斯的化物.
- 类化合物包括细胞类,二基多类,金纳类,金类,类,类和类.
- 这些化合物表现出多种生物活性,包括抗菌,细胞毒性,抗炎和酶抑制作用 (α-葡萄糖酶,ACE,DPPH).
结论:
- 内生性阿斯伯吉洛菌是结构多样化和生物活性类化合物的丰富来源.
- 这些类化合物对药物发现和开发具有重大潜力.
- 对Aspergillus衍生的类化合物的进一步研究可能会导致新的治疗剂.
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