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康宁宁X-Z,三种来自Trichoderma koningiopsisSC-5的新型多基基菌

Weiwei Peng^1,2, Jianbing Tan^1,2, Zihuan Sang^1,2,3

¹Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Molecules (Basel, Switzerland)

|December 9, 2023

概括

从Trichoderma koningiopsis真菌中发现了三种新的多基基类物质Koninginins X-Z. 这些化合物在结构上进行了分析,并测试了对Candida albicans的抗真菌特性.

科学领域:

自然产品化学化学
菌类学菌类学是指菌类学.
药用化学医学化学

背景情况:

内生菌是新生物活性二次代谢产物的丰富来源.
众所周知,Trichoderma物种可以产生各种各样的多基,具有潜在的制药应用.

研究的目的:

从内性真菌Trichoderma koningiopsis SC-5中分离和描述新型的多基基菌.
阐明分离化合物的结构,包括它们的绝对配置.
评估分离的化合物的抗真菌活性,以对抗Candida albicans.

主要方法:

这是Trichoderma koningiopsis SC-5的固体发酵.
使用NMR光谱方法 (1D和2DNMR,13CNMR,DFT GIAO 13CNMR) 阐明结构.
高分辨率的电喷射电离化质谱仪 (HRESIMS).
电子循环二元化 (ECD) 计算.电子循环二元化计算.
单晶X射线衍射分析.
对Candida albicans的抗真菌活性测定.

主要成果:

三种名为Koninginins X-Z (化合物1-3) 的新型多基菌被分离和鉴定出来.
使用光谱和计算方法的组合确定了Koninginins X-Z的完整结构和绝对配置.
化合物1-3被评估为它们对Candida albicans的抗真菌活性.

结论:

植物内菌Trichoderma koningiopsis SC-5可以产生一种新型的多基菌,Koninginins X-Z.
详细的结构特征为多基化工提供了宝贵的数据.
需要进一步研究这些化合物的抗真菌潜力.

关键词:

三甲虫 (Trichoderma koningiopsis) 是一种有毒的植物.抗真菌活动的抗真菌活性.它们是内性真菌.聚基化物是一种多基化物.二次代谢产物二次代谢产物

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