在疾病修饰疗法下多发性硬化症患者中SARS-CoV-2的血清流行:一项多中心研究
Agustín Sancho-Saldaña1,2, Anna Gil-Sánchez2, Cristina González-Mingot1
1Neurology Department, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomèdica de Lleida-IRBLleida, 25198 Lleida, Spain.
Journal of clinical medicine
|December 9, 2023
概括
接受疾病修饰疗法 (DMT) 的多发性硬化症 (pwMS) 患者表现出更高的COVID-19血清流行率. 干扰素治疗与抗体存在的增加相关,这表明该人群的免疫反应强大.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 该EMCOVID项目调查了COVID-19对多发性硬化症 (pwMS) 患者对疾病修饰疗法 (DMT) 的影响.
- 由于免疫系统相互作用和DMT免疫调节效应,人们对pwMS对COVID-19的易感性存在担忧.
研究的目的:
- 在EMCOVID数据库中评估MS患者的SARS-CoV-2抗体血清流行和持续性.
- 评估人口统计,MS表型,DMT和COVID-19结果之间的关系.
主要方法:
- 一项前性观察性研究,使用来自EMCOVID-19队列的数据.
- 提取了人口统计,多发性硬化病史,实验室,SARS-CoV-2血清学和COVID-19症状数据.
- 在6个月的时间内评估了SARS-CoV-2抗体的演变.
主要成果:
- 与普通人群相比,pwMS中观察到较高的SARS-CoV-2抗体血清流行率 (16.9%与干扰素治疗的8.4%相比,p=0.003).
- 干扰素治疗与较高的血清流行率有显著的关联;没有其他DMT显示出显著的关联.
- 大多数pwMS无症状;预后通常有利,即使是有症状的病例.
结论:
- 在DMT上的PwMS显示COVID-19血清流行率增加,干扰素治疗与更强大的幽默反应有关.
- 这项研究提供了有关SARS-CoV-2抗体血清流行率和 pwMS.持续性的见解.
- 这些发现有助于理解COVID-19对这一患者群体的影响.
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...


