在患有炎症性肠病的患者中血液综合评分
Marta Carrillo-Palau1, Belén Vera-Santana1, Andrea Morant-Domínguez1
1Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Journal of clinical medicine
|December 9, 2023
概括
炎症性肠病 (IBD) 患者的中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 比对照组更高. 然而,这些和其他炎症标志物与克罗恩病或性结肠炎的疾病活性没有相关性.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
背景情况:
- 炎症性肠病 (IBD) 涉及慢性免疫系统失调.
- 血液学复合评分,包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),单细胞与淋巴细胞的比率 (MLR) 和全身免疫炎症指数 (SIRI),被探索为潜在的炎症生物标志物.
- 评估IBD患者与健康对照者的这些分数及其与疾病活动的相关性对于诊断和预后见解至关重要.
研究的目的:
- 在IBD患者和健康对照者之间调查血液综合分数 (NLR,PLR,MLR,SIRI) 的差异.
- 确定这些血液学分数与IBD中的疾病活性之间的关联,包括克罗恩病 (CD) 和性结肠炎 (UC).
主要方法:
- 分析了197名IBD患者 (130名CD,67名UC) 和208名健康对照的队列.
- 血液样本被用于计算NLR,PLR,MLR和SIRI.
- 测量C-反应蛋白和便calprotectin水平以评估炎症和疾病活动.
- 使用多变量线性回归分析来评估变量之间的关系.
主要成果:
- 与对照组相比,IBD患者的NLR和PLR在统计调整后显著升高.
- 在IBD患者和对照人群之间,SIRI和MLR没有显示出显著的差异.
- 在IBD患者中与SIRI和NLR相关的C-反应蛋白.
- 便calprotectin和疾病活性参数与CD或UC患者评估的基于血液的炎症评分没有关联.
结论:
- 在IBD患者中,NLR和PLR的独立性更高,表明它们作为一般炎症标志物的潜力.
- 尽管IBD中NLR和PLR升高,但四个血液学得分中的任何一个都不能可靠地反映CD或UC中的疾病活性.
- 基于血液的炎症评分可能不适合作为替代生物标志物来监测IBD中的疾病活性.
更多相关视频
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
9.4K
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
31.8K
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
188
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
188
01:30Inflammatory Bowel Disease II: Crohn's Disease
253
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
253
01:17Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
01:29Inflammatory Bowel Disease IV: Pharmacological Management
129
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
129
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
168
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
168