类风湿性关节炎患者心血管疾病的慢性反应和危险因素:一个横截面研究
Ahmad M Osailan1,2,3, George S Metsios2,4, Joan L Duda3
1Health and Rehabilitation Sciences Department, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj 16278, Saudi Arabia.
类风湿性关节炎患者通常具有降低的慢性反应 (CR),与心血管疾病 (CVD) 风险相关. 诸如HDL和心肺健康 (VO2PEAK) 等因素在RA中显著影响CR.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 运动生理学 运动生理学
背景情况:
- 类风湿性关节炎 (RA) 患者面临心血管疾病 (CVD) 的风险增加.
- 降低的慢性反应 (CR) 是已知的心血管疾病和死亡率的贡献者,并且在RA患者中观察到.
- 在RA中影响CR的因素仍然不完全理解.
研究的目的:
- 在RA患者中调查与降低CR相关的因素.
- 探索CR和CVD风险因素,炎症标志物和心肺呼吸能力 (VO2PEAK) 之间的关系.
主要方法:
- 106名RA患者完成了跑步机测试与心率监测.
- 评估包括血清性心血管疾病风险因素,炎症标志物和VO2PEAK.
- 回归分析确定了独立的CR相关因素.
主要成果:
- 34%的参与者表现出降低的CR (≤80%).
- 降低CR与体重指数,HOMA,hsCRP和纤维素因子相反相关.
- HDL,QUICKi,VO2PEAK和RER显示出与CR的积极关联,HDL和VO2PEAK是独立的预测因素.
结论:
- 在RA中降低CR与特定的心血管疾病风险因素,炎症标志物和心肺呼吸能力有关.
- 高密度胆固醇和VO2PEAK是与RA中CR相关的关键独立因素.
- 进一步的研究应检查针对这些因素的干预措施,以改善RA患者的CR.
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