升高的HDL胆固醇,体重指数和甲状腺结节的存在之间的相关性:回顾性分析
Cafer Zorkun1, Kenan Yalta2, Alara Eren3
1Department of Cardiology, Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
Journal of clinical medicine
|December 9, 2023
概括
高密度脂蛋白胆固醇 (HDL胆固醇) 的升高可能表明甲状腺结节,特别是在体重指数 (BMI) 高的女性中. 这一发现表明,在这种情况下,HDL胆固醇可能是一个指标,而不是心血管保护标记.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 高密度脂蛋白胆固醇 (HDL胆固醇) 的升高与不良结果有关,但其与甲状腺结节的关联尚未得到充分证实.
- 甲状腺结节很常见,了解它们的预测因素对于患者管理至关重要.
研究的目的:
- 为了研究高高的HDL胆固醇水平和甲状腺结节的存在之间的相关性.
- 为了确定与甲状腺结节相关的人口和临床因素,与HDL胆固醇相关.
主要方法:
- 对677名患者的回顾性分析,按体重指数 (BMI) 分类<25,25-29和≥30.
- 对人口统计数据,心率和高脂胆固醇水平的评估.
- 多变量回归分析以确定甲状腺结节的独立预测因子.
主要成果:
- 在67.1%的队列中发现了甲状腺结节;左心室扩张功能障碍 (LVDD) 在58.1%.
- 体重指数 (BMI),心率和高密度胆固醇是甲状腺结节的独立预测指标 (p=0.000).
- 甲状腺结节在女性中更为普遍,特别是BMI较高的人 (OR=1.048-1.115),但在男性中并不如此.
结论:
- 升高的HDL胆固醇可以作为甲状腺结节的指标.
- 连接HDL胆固醇和甲状腺结节的精确机制需要进一步研究.
- 研究结果表明,在这种情况下,HDL胆固醇的作用可能与其典型的心血管保护功能不同.
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