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大动脉生物假体植入后的血小板减少:来自PORTRAIT研究的结果

Federica Jiritano^1,2,3, Giuseppe Filiberto Serraino¹, Michele Di Mauro²

¹Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.

Journal of clinical medicine

|December 9, 2023

概括

大动脉生物假体植入后的血小板减少 (PR) 是常见的和短暂的. 快速部署 (RDV) 与更大的PR和不良事件有关,包括缺血性中风.

科学领域:

心血管外科心血管外科
血液学血液学血液学
生物材料科学生物材料科学

背景情况:

血小板数减少 (PR) 是一个频繁的前大动脉生物假体植入后 (生物-AVR) 的并发症.
确切的机制和PR的临床意义仍然不清楚.
本研究评估了不同类型的生物假体的PR:支架式,快速部署 (RDV) 和无支架式.

研究的目的:

调查生物AVR后PR的发生率和临床影响.
为了比较支架,RDV和无支架生物假体之间的PR率.
确定与PR相关的因素及其与不良结果的相关性.

主要方法:

分析了1233名接受生物AVR的成年患者队列.
评估了血小板数变化,早期术后不良事件和住院死亡率.
患者根据植入的生物假体类型进行分类:支架,RDV或无支架.

主要成果:

与基线相比,所有生物AVR组在出院时血小板数量显著下降.
在RDV (56%) 和无支架 (55%) 组中,PR发生率高于支架组 (27%).
RDV患者显示出更大的PR,与增加的住院不良事件和缺血性中风相关,无论生物假体类型.

结论:

生物AVR与显著的,尽管是短暂的,PR相关.
RDV植入与更高的实质性PR和相关不良临床事件的可能性有关.
PR是生物AVR后缺血性中风的重要预测因子.

关键词:

大动脉门更换术生物假肢是一种生物假肢.血小板血小板血小板是什么?血小板细胞减少症 (Thrombocytopenia) 是一种

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