作为预测血液透析患者全因死亡率的潜在标记物,Endocan
Jia-Hong Lin1, Bang-Gee Hsu2,3, Chih-Hsien Wang2,3
1Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Journal of clinical medicine
|December 9, 2023
概括
较高的血清内分泌水平与血液透析患者死亡风险增加有关. 这一发现表明血清内分泌素可能作为预测这一群体死亡率的重要生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 生物标志物发现发现
背景情况:
- 内分泌,一种促炎和促血管性因素,表明内皮功能障碍,与心血管疾病有关.
- 心血管疾病是血液透析 (HD) 患者的主要死亡原因.
研究的目的:
- 调查血清内分泌水平与在维持血液透析的患者中因任何原因死亡率之间的关联.
- 确定潜在的生物标志物,以预测HD患者死亡风险.
主要方法:
- 一项前性队列研究包括103名血液透析患者,持续36个月.
- 血清内分泌,肌素,白蛋白和其他临床数据在基线收集.
- 死亡事件被记录并根据基线特征和生物标志物进行分析.
主要成果:
- 在随访期间,共有26人死亡 (25.2%).
- 较高的血清内分泌水平和较低的血清肌素水平在调整预后变量后显著与所有原因死亡率的增加有关.
- 诸如糖尿病和老年等因素也与较高的死亡风险相关.
结论:
- 血清内分泌水平升高和血清肌素水平降低独立地与血液透析患者的全因死亡率有关.
- 血清内分泌体显示出作为血液透析患者死亡风险预测生物标志物的潜力.
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