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肝细胞癌中瘤微环境的复杂性和新兴的治疗发展

Antonella Argentiero¹, Antonella Delvecchio², Rossella Fasano¹

¹Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.

Journal of clinical medicine

|December 9, 2023

概括

本综述详细介绍了肝细胞癌瘤微环境 (TME),重点关注细胞和非细胞元素. 它讨论了治疗策略和巴塞罗那诊所肝癌分期系统,以改善患者的治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物化学生物化学

背景情况:

瘤微环境 (TME) 对肝细胞癌 (HCC) 的发展和进展至关重要.
像癌症相关纤维细胞 (CAF) 和免疫细胞 (TAM,MDSC,Tregs) 这样的细胞组件创造了一个免疫抑制的环境.
非细胞成分,包括细胞外基质 (ECM) 和缺氧诱导的血管生成,也驱动瘤生长和转移.

研究的目的:

综合审查HCC TME的细胞和非细胞组件.
阐明它们在瘤进展,免疫逃避和治疗耐药性方面的作用.
探索新兴的TME向疗法和巴塞罗那诊所肝癌 (BCLC) 阶段系统的实用性.

主要方法:

对HCC TME现有研究的文献综述.
细胞组件的分析:CAFs,TAMs,MDSCs,Tregs. 这些都是细胞组件的分析.
对非细胞组件的检查:ECM,缺氧,血管生成,HIF,VEGF信号传递.

主要成果:

CAFs促进HCC的进展,血管生成,免疫抑制和治疗耐药性.
免疫细胞有助于免疫抑制的TME,促进瘤生长和免疫逃避.
电脑细胞膜变化和缺氧驱动的血管新生促进侵袭,转移和瘤生长,涉及HIF和VEGF通路.

结论:

针对HCC TME提供了有前途的治疗策略,包括二线治疗,如regorafenib,cabozantinib和ramucirumab.
BCLC分期系统有助于对HCC患者的治疗分层和预后预测.
了解复杂的HCC TME对于开发个性化治疗和改善临床结果至关重要.

关键词:

在BCLC的分期和分类.生物标志物生物标志物肝细胞癌是肝细胞癌.免疫疗法免疫疗法有针对性的治疗.瘤微环境是一个微环境.

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