聚糖酸Agaricus blazei通过调节肠道屏障和重塑新陈代谢来缓解小鼠DSS诱导的大肠炎
Zhong-Hao Ji1,2, Song He1, Wen-Yin Xie1
1Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, China.
Nutrients
|December 9, 2023
概括
阿加里克斯·布莱泽 (Agaricus blazei) 补充的穆里尔多糖 (ABP) 减轻了小鼠性结肠炎 (UC) 的症状. ABP保护肠道屏障,减少炎症,并对肠道微生物群和新陈代谢产生积极影响.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,影响生活质量.
- 阿加里克斯·布莱泽 (Agaricus blazei) 穆里尔多糖 (ABP) 显示出超出其已知的作用的潜在治疗益处.
研究的目的:
- 在小鼠中研究ABP对硫酸 (DSS) 诱导的急性结肠炎的保护作用.
- 阐明ABP在结肠炎中的作用的潜在机制.
主要方法:
- 在小鼠模型中使用DSS诱导急性结肠炎.
- 评估临床症状,炎症标志物和氧化应激.
- 对肠道屏障完整性 (ZO-1,Occludin) 和粘液分泌的分析.
- 用于肠道微生物群分析的16S rRNA测序.
- 用于代谢分析的非目标代谢组.
主要成果:
- 服用ABP补充剂显著降低了结肠炎症状,炎症和氧化应激.
- 通过调节紧密结蛋白 (ZO-1,Occludin) 和粘液分泌,ABP促进了肠道屏障的完整性.
- 通过ABP干预,可以减轻DSS诱导的肠道微生物群失调.
- 代谢学发现ABP重塑了宿主代谢.
结论:
- 饮食ABP显示出对DSS诱导的急性结肠炎具有显著的保护作用.
- ABP维持肠道屏障功能,调节肠道微生物群和新陈代谢.
- 作为预防性结肠炎的食补充剂,ABP显得有前途.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
145
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
145
Drugs for Treatment of Diarrhea-Predominant IBS
179
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
179
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
Inflammatory Bowel Disease IV: Pharmacological Management
129
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
129


