骨质疏松症和骨质疏松症中的明显代谢物:系统性审查和元分析
Yuhe Wang1, Xu Han2, Jingru Shi1
1Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Nutrients
|December 9, 2023
概括
不同的代谢物与骨质疏松症和骨质疏松症有关. 这次审查发现了氨基酸,脂质和碳水化合物的特定变化,其中一些可能预测骨质疏松症风险.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生化学
- 骨健康 骨健康 骨健康
背景情况:
- 骨质疏松症 (ON) 和骨质疏松症 (OP) 涉及不同的代谢途径.
- 目前还没有对这些代谢物的标准化分类.
- 了解这些代谢差异对于诊断和治疗至关重要.
研究的目的:
- 系统地审查和对ON和OP患者不同代谢物的现有文献进行元分析.
- 为了分类和标准化与ON和OP相关的代谢物.
- 为了确定骨质疏松症的潜在代谢物生物标志物.
主要方法:
- 对21篇相关文章进行了系统审查和元分析.
- 使用以星为基础的系统对产品质量的评估.
- 与对照组相比,对ON和OP患者的代谢物水平 (增加,减少或冲突) 的分析.
主要成果:
- 系统性审查确定了OP/ON中脂质,碳水化合物,氨基酸和其他代谢物的变化.
- 分析证实OP患者的甘油甘氨酸 (gly-gly) 和囊的水平下降.
- 分析结果显示,OP患者的lysophosphatidylcholine (LPC) 水平增加.
结论:
- 不同的代谢物与骨质疏松症和骨质疏松症有显著的关联.
- 某些特定的代谢物,如甘油甘氨酸,囊和lysophosphatidylcholine显示出作为生物标志物的承诺.
- 这些发现可能会导致改善骨质疏松症的预测和管理策略.
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