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床边的乳病:在住院儿童中嵌入病例发现和查

Angela Pepe¹, Claudia Mandato¹, Tiziana Di Leo²

¹Pediatrics Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.

|December 9, 2023

概括

意大利南部住院的儿童患乳病 (CD) 患病率为1.59%,与人口查计划相似. 在例行抽血期间进行测试可能会提高诊断率.

科学领域:

儿科胃肠病学儿科胃肠病学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

结核病 (CD) 诊断依赖于病例发现和人口查,查显示了更高的检测率,但仍然存在争议.
全球CD患病率约为1%,但查计划可以显示几乎是这一比例的两倍,特别是在学龄儿童中.
这项研究调查了意大利南部住院儿童中CD的患病率以及相关的临床指标.

研究的目的:

估计住院儿科患者中乳病 (CD) 的患病率.
为了确定这个队伍中乳性疾病自身免疫 (CDA) 的流行率.
探索诊断时与吸收不良/营养不良和全身炎症相关的临床警报的频率.

主要方法:

住院儿科病例记录的回顾性分析测试了抗转胺酶IgA抗体 (TGA-IgA).
诊断CD遵循2012年或2020年ESPGHAN指南.
乳性疾病自身免疫 (CDA) 定义为TGA-IgA升高,不论活检或抗内性抗体确认.

主要成果:

在入院的3608名儿科患者中,有1320名 (36.6%) 接受了CD检查.
新诊断的CD的患病率为1.59% (21名患者),CDA的患病率为3.86% (51名受试者).
在被诊断为CD患者中,28.6%的患者体重不足或营养不良.

结论:

住院儿童中CD诊断的患病率与人口查计划相比较.
CDA的患病率明显高于被诊断为CD.
在住院期间进行常规的CD检测提供了一种具有成本效益的,非侵入性的方法,以弥合病例发现和人口查之间的差距.

关键词:

调查案件的调查.患有乳性疾病的患者.住院儿童住院儿童吸收不良的情况患病率的流行情况.查检查查检查查检查查检查

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