葡萄糖6酸脱酶缺乏症与注意力缺陷/多动障碍之间的关联
Eugene Merzon1,2, Eli Magen3, Shai Ashkenazi1
1Adelson School of Medicine, Ariel University, Ariel 40776, Israel.
Nutrients
|December 9, 2023
概括
葡萄糖-6-酸盐脱酶 (G6PD) 缺乏与较高的注意力缺陷/多动症 (ADHD) 诊断风险和更严重的ADHD表现有关. 这表明G6PD缺乏可能表明对ADHD精神病药物的需求更大.
科学领域:
- 医学遗传学 医学遗传学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 葡萄糖-6-酸盐脱酶 (G6PD) 缺乏症是一种常见的酶变症,影响全球人口的4.9%.
- 这种情况在地中海社区尤为普遍,并与神经系统疾病有潜在的联系.
- G6PD缺陷与注意力缺陷/多动障碍 (ADHD) 之间的关联值得研究.
研究的目的:
- 调查葡萄糖-6-酸盐脱酶 (G6PD) 缺乏和注意力缺陷/多动症障碍 (ADHD) 之间的联系.
- 分析患有G6PD缺乏症的个体中ADHD诊断和治疗模式的风险.
主要方法:
- 一项大型队列研究分析了7473名G6PD缺乏患者和29892名来自1,031,354人的匹配对照.
- 临床特征使用费舍尔的精确测试对分类数据和曼-惠特尼U测试对连续数据进行评估.
- 随访持续时间平均为14.3年,分析时平均年龄为29.2岁.
主要成果:
- G6PD缺乏与ADHD诊断的风险增加显著相关 (OR = 1.16).
- 患有G6PD缺乏症的个人寻求神经病学家 (OR = 1.30) 和精神病学家 (OR = 1.12) 的治疗率更高.
- 刺激药物的使用,包括甲基酸盐和安非他命,在G6PD缺乏的个体中升高.
结论:
- 缺乏G6PD是ADHD诊断的一个重要风险因素.
- 研究结果表明,G6PD缺乏可能与更严重的ADHD症状和增加对精神病药物治疗的需求有关.
- 建议对连接G6PD缺乏和ADHD的潜在机制进行进一步研究.
关键词:
注意缺陷多动障碍 (ADHD) 是一种注意缺陷多动障碍.葡萄糖6酸盐脱酶 (G6PD) 的使用心理健康 心理健康神经发育障碍是一种神经发育障碍.神经炎症是一种神经炎症.氧化应激是一种氧化应激.一个体质的体质.更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.7K
05:44Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
599
相关概念视频
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Glucose Transporters
22.8K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.8K
Inborn Errors of Metabolism
164
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
164
Human Genetics
583
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
583
Diabetes: Symptoms, Diagnosis, and Complications
554
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
554
Pathophysiology of Diabetes
949
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
949
