牙脱落与胰岛素抵抗之间的关联由饮食质量和全身免疫炎症指数介导
Yaqi Hao1,2, Shaoru Li3, Shaojie Dong1,2,4
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
牙损失与胰岛素抵抗 (IR) 的增加有关,饮食质量和全身免疫炎症指数 (SII) 起着调解作用. 改善饮食和减少SII可能有助于预防IR和相关疾病.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 营养科学 营养科学
背景情况:
- 牙脱落和糖尿病 (以胰岛素抵抗为特征) 是全球普遍存在的健康问题.
- 现有的研究表明,牙脱落和糖尿病之间存在联系,但这种关系的性质和潜在的调解因素需要进一步调查.
研究的目的:
- 为了研究胰岛素抵抗 (IR) 和牙损失之间的关系.
- 检查系统性免疫炎症指数 (SII) 和饮食质量在牙脱落和IR之间的关联中扮演的调解角色.
主要方法:
- 利用了来自全国健康和营养检查调查 (NHANES) 的横截面数据,涉及8197名参与者.
- 采用回归模型来评估IR,牙脱落,饮食质量 (健康饮食指数-2015) 和SII之间的关联.
- 应用了引导链接来测试调解效果.
主要成果:
- 较高的牙损失与增加的IR (HOMA-IR) 和较差的饮食质量 (较低的HEI-2015分数) 相关联.
- 增加的SII和不充分的饮食质量是IR的风险因素,而最佳的饮食质量提供了保护.
- 饮食质量和SII部分调解了牙脱落和IR之间的关系,总调解效应分别约为4.7%和4.6%.
结论:
- 失去牙与增加的胰岛素抵抗有关.
- 饮食质量和SII水平是牙损失与IR关系的重要调解因素.
- 专注于改善饮食质量和减少SII的干预措施可以提供预防和管理IR和相关疾病的策略.
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