相关实验视频

Updated: Jul 9, 2025

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

在患有代谢综合征的患者中,宿主遗传变异和下微生物群之间的关联

Luigi Nibali¹, Abish S Stephen², Robert P Allaker²

¹Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK.

International journal of molecular sciences

|December 9, 2023

概括

宿主遗传变异会影响代谢综合征患者口腔微生物组的组成. 特定的基因变异与与严重牙周炎相关的致病细菌相关,影响口腔和全身健康.

科学领域:

遗传学遗传学是一个
微生物学微生物学
牙周病学牙周病学

背景情况:

宿主遗传变异可以影响口腔生物膜和牙周炎-全身性疾病轴.
代谢综合征 (MetS) 与牙周炎风险增加有关.
主体遗传学,口腔微生物群和MetS之间的相互作用仍未得到充分探索.

研究的目的:

在患有MetS.的患者中调查宿主遗传变异和下微生物群之间的关联.
探索这些关联是如何根据牙周状况而有所不同.

主要方法:

103名MetS患者接受了医疗和牙周检查.
采集了下斑块和血液样本,用于DNA提取和微生物组分析.
分析了单核酸多态 (SNP),随后进行了微生物组分析和关联测试.

主要成果:

在RUNX2,CAMTA1和VDR基因中的特定SNP与口腔微生物群多样性指标相关联.
对于牙周炎的严重程度或MetS组件,没有发现全基因组相关性.
包括VDR (rs12717991) 和RUNX2 (rs3749863) 在内的SNP与Streptococcus mutans和Porphyromonas gingivalis.com等特定细菌存在相关性.

结论:

宿主基因型变异可能导致牙周炎的免疫失调.
与MetS相关的全身健康特征与口腔健康和微生物群相互作用.
这项研究为MetS.口腔微生物组的遗传基础提供了新的见解.

关键词:

心血管疾病心血管疾病代谢综合征代谢综合征牙周疾病牙周疾病牙周炎是指牙周炎的一种疾病.

更多相关视频

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...