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污染物对皮肤炎症细胞激活效应的比较

John Ivarsson¹, Francesca Ferrara², Andrea Vallese^3,4

¹Department of Food, Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, NC Research Campus, NC State University, Kannapolis, NC 28081, USA.

International journal of molecular sciences

|December 9, 2023

概括

臭氧,微塑料和紫外线等环境污染物引发皮肤氧炎和衰老. 特定的炎症体 (NLRP1,NLRP6) 是防止污染引起的皮肤损伤和炎症的关键目标.

科学领域:

皮肤病学皮肤病学
环境科学环境科学
毒理学毒理学毒理学

背景情况:

皮肤最外层面临环境压力因素,包括引发氧炎的污染物.
在对空气污染物和紫外线辐射的反应中调节皮肤炎症的过程中,炎症酶是至关重要的.

研究的目的:

研究特定的空气污染物 (微塑料,香烟烟雾,柴油废气,臭氧,紫外线) 如何对皮肤氧炎标志物产生不同影响.
探索炎症酶通路 (NLRP1,NLRP3,NLRP6,NLRC4) 在应对污染物暴露和它们对皮肤衰老的影响中的作用.

主要方法:

人类皮肤爆炸物被暴露在各种环境污染物中1或4天.
评估了氧化应激,DNA损伤,皮肤过早衰老标志物,炎症酶激活 (支架形成) 和热.

主要成果:

污染物暴露导致氧化应激,DNA损伤和皮肤过早衰老的迹象.
臭氧 (O3),微塑料 (MP) 和紫外线被确定为皮肤氧化还原失衡的主要贡献者.
这些户外压力因素显著调节了NLRP1和NLRP6炎症酶.

结论:

臭氧,微塑料和紫外线暴露显著影响皮肤氧化还原平衡,并触发炎症细胞通路.
准NLRP1和NLRP6炎症酶可能提供一种预防环境污染物引起的皮肤疾病和炎症的策略.

关键词:

一些炎症一些炎症氧气炎症是一种炎症.污染物污染物污染物皮肤皮肤皮肤

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