通过放射治疗调节CD8+ T细胞反应 - - 目前的证据和结合免疫检查点抑制剂的理由
Seung Hyuck Jeon1, Changhoon Song1, Keun-Yong Eom1
1Department of Radiation Oncology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
International journal of molecular sciences
|December 9, 2023
概括
放射治疗通过调节CD8+T细胞来增强抗瘤免疫力. 本综述探讨了辐射如何影响这些关键的免疫细胞及其在结合癌症治疗中的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
- 癌症治疗 癌症治疗
背景情况:
- 众所周知,放射治疗会影响免疫细胞的反应,特别是对抗瘤免疫力至关重要的CD8+ T细胞.
- 免疫检查点抑制剂的成功刺激了人们对辐射调节CD8+T细胞活性的能力的兴趣.
- 新出现的证据表明,放射治疗可以有益地影响抗瘤免疫力.
研究的目的:
- 审查目前关于放射治疗后CD8+T细胞变化的知识.
- 描述直接和间接的生物学机制,是辐射诱导免疫调节的基础.
- 讨论将放射治疗与免疫检查点抑制剂结合在一起的潜力.
主要方法:
- 关于放射治疗后CD8+T细胞反应的临床前和临床研究的综述.
- 通过辐射对免疫调节的生物机制的分析.
- 对放射治疗和免疫检查点抑制剂组合的现有证据的评估.
主要成果:
- 放射治疗可以调节CD8+T细胞的反应,可能增强抗瘤免疫力.
- 直接和间接的生物机制都会导致这些免疫变化.
- 许多临床试验正在研究与免疫检查点抑制剂结合的放射治疗.
结论:
- 放射治疗在通过CD8+T细胞调节来增强抗瘤免疫力方面显示出前景.
- 了解这些机制对于优化组合疗法至关重要.
- 进一步的研究对于利用免疫检查点抑制剂有效利用放射治疗至关重要.
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