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马的早期割不会影响骨关节代谢
Marion Rouge1, Florence Legendre2, Razan Elkhatib1
1Université de Caen-Normandie, OeReCa, 14000 Caen, France.
International journal of molecular sciences
|December 9, 2023
概括
马的早期割,在出生后不久进行,不会对骨和软骨健康产生负面影响. 这项研究发现,与18个月的传统割相比,骨关节代谢标志物没有显著差异.
科学领域:
- 马的内分泌学和代谢.
- 骨关节健康研究 骨关节健康研究
- 动物生理学的比较
背景情况:
- 传统马割发生在青春期后 (大约2岁).
- 有限的研究存在于早期割对马骨关节代谢的影响.
- 马类骨和软骨中的类固醇激素合成和受体表达需要进一步研究.
研究的目的:
- 为了比较早期割 (出生后3天) 与传统割 (18个月) 对马的骨关节代谢的影响.
- 分析从出生到33个月的类固醇激素 (,雌激素) 概况.
- 为了评估骨和软骨的生物标志物,可分化/可解化,关节炎和炎症.
主要方法:
- 从出生到33个月的早期和传统割马的丸激素和雌激素水平的监测.
- 软骨和骨的代谢 (CPII,N-MID) 和代谢 (CTX-I,CTX-II) 的生物标志物的量化.
- 测量骨关节炎 (HA, COMP) 和炎症 (IL-6, PGE2) 标志物,以及雌激素 (ESR1) 和雄激素 (AR) 受体表达.
主要成果:
- 在两组中,在分娩后和青春期观察到异步的和雌激素合成.
- 检测到28个月左右的额外腺类固醇合成,无论割时间如何.
- 在软骨和骨中发现雌激素受体 (ESR1),在骨中发现雄激素受体 (AR).
- 早期割并没有改变骨关节代谢生物标志物,骨关节炎标志物或炎症水平.
结论:
- 马的早期割不会对骨和软骨的平衡产生不利影响.
- 早期割后的类固醇激素剥夺对骨关节代谢标志物没有明显的影响.
- 雌激素和雄激素受体存在于马类骨和软骨中,这表明它们可能在新陈代谢中发挥作用.
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