经过中央勒素给药和饮食诱导的肥胖症后,多器官增加的诺亚上腺素水平
Daniela Fernandois1, María Jesús Vázquez2,3,4, Alexia Barroso2,3,4
1Center for Neurobiochemical Studies in Endocrine Diseases, Laboratory of Neurobiochemistry, Department of Biochemistry and Molecular Biology, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago 7820436, Chile.
International journal of molecular sciences
|December 9, 2023
概括
大脑中的瘦素增加了像肝脏和卵巢这样的器官中的交感神经活动. 这一发现表明素.
科学领域:
- 神经内分泌学神经内分泌学
- 自主神经系统的调节规则
- 代谢的恒常状态 代谢的恒常状态
背景情况:
- 自主内置对于维持所有器官的恒温至关重要.
- 交感神经系统调节新陈代谢和生殖,影响脂肪组织,肝脏和卵巢.
- 脑下垂体神经元控制交感活动,受到勒素等激素的影响.
研究的目的:
- 为了研究丁在大脑中的作用是否会影响肝脏和卵巢的交感内置.
- 为了探索勒素,同情活动和器官北上腺素水平之间的联系.
主要方法:
- 在动物中注射脑内内 (ICV) 丁.
- 使用ELISA和HPLC-EC.EC测量各种器官 (脂肪组织,肝脏,卵巢) 中的诺亚上腺素水平.
- 对一种饮食诱导的肥胖模型进行评估,以评估勒丁和北上腺素水平.
主要成果:
- 在肝脏和卵巢中,ICV勒丁的使用导致了北上腺素水平的升高.
- 饮食诱导的肥胖与肝脏和卵巢中勒丁和北上腺素的增加相关.
- 超血可能会导致这些器官的交感性过活.
结论:
- 大脑中的勒素信号调节了对肝脏和卵巢的同情性内化.
- 由于高血压导致的上腺素的升高可能在非酒精性脂肪肝疾病和多囊性卵巢综合征的发病过程中发挥作用.
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