线粒体在炎症性肠病中的作用:系统性审查
María José Sánchez-Quintero1,2,3, Cristina Rodríguez-Díaz1,4, Francisco J Rodríguez-González1,4
1Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
International journal of molecular sciences
|December 9, 2023
概括
线粒体功能障碍通过影响肠道健康,免疫反应和修复机制,显著影响炎症性肠道疾病 (IBD). 这篇评论探讨了线粒体.
科学领域:
- 细胞生物学 细胞生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 线粒体对于细胞能量生产至关重要 (通过氧化酸化产生ATP),并承载着众多代谢和生物合成途径.
- 除了生物能量之外,线粒体调节细胞的氧化还原平衡,排毒,并与各种复杂的疾病有关.
- 炎症性肠道疾病 (IBD),包括性结肠炎和克罗恩病,是慢性肠道炎症疾病.
研究的目的:
- 审查当前关于线粒体功能障碍在炎症性肠病 (IBD) 发病过程中的作用的知识.
- 在IBD背景下讨论线粒体在肠道粘膜和免疫细胞中的参与.
- 探索线粒体功能对粘膜修复,微生物群和脑肠轴以及结肠炎相关的结肠直肠癌的影响.
主要方法:
- 文献综述综合了当前关于线粒体和IBD的研究.
- 对检查肠道上皮细胞和免疫群体中线粒体作用的研究进行分析.
- 检查证据,将线粒体功能障碍与IBD相关机制和并发症联系起来.
主要成果:
- 线粒体功能障碍越来越被认为是IBD发展和进展的重要因素.
- 线粒体影响肠道屏障的完整性,免疫细胞的激活,以及肠道的炎症反应.
- 功能障碍的线粒体与IBD中的粘膜愈合受损和肠-大脑-微生物群信号改变有关.
结论:
- 线粒体健康对于维持肠道平衡至关重要,并且在炎症性肠道疾病中受到损害.
- 准线粒体通路可能为IBD管理提供新的治疗策略.
- 需要进一步的研究,以充分阐明线粒体和IBD病原体之间的复杂相互作用.
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