患有多动症儿童家庭地中海热的增加率:基于人口的病例对照研究
Eugene Merzon1,2, Ariel Israel3, Beth Krone4
1Lehumit Health Services, Tel-Aviv, Israel.
Journal of attention disorders
|December 9, 2023
概括
患有家族地中海热 (FMF) 的儿童患有注意力缺陷/多动障碍 (ADHD) 的风险更高. 这项研究发现,在儿童中,先前的FMF诊断和后来的ADHD诊断之间存在显著的关联.
科学领域:
- 儿科健康 儿科健康
- 神经发育障碍 神经发育障碍
- 炎症性疾病 炎症性疾病
背景情况:
- 越来越多的证据将炎症机制与注意力缺陷/多动障碍 (ADHD) 联系起来.
- 以前的研究表明,在患有家族地中海热 (FMF) 的儿童中,ADHD的患病率更高.
研究的目的:
- 调查家庭地中海热 (FMF) 的先前诊断与儿童注意力缺陷/多动障碍 (ADHD) 的后续诊断之间的关联.
- 为了确定FMF是否是发展ADHD的危险因素.
主要方法:
- 基于人口的病例控制研究使用Leumit健康服务 (01.01.200606.30.2021) 的数据进行.
- 符合ICD-9/10标准的ADHD (病例) 的儿童与基于年龄,性别和社会经济地位的非ADHD对照进行了1:2匹配.
主要成果:
- 与对照组 (0.17%) 相比,ADHD儿童的比例更高,他们之前有FMF诊断 (0.30%).
- 在之前的FMF诊断和后来的ADHD诊断之间发现了一个显著的,独立的关联 (OR = 1.72,95% CI 1.18-2.51,p = .003).
结论:
- 这些发现表明,家族地中海热病与患注意力缺陷/多动障碍的风险增加之间存在显著的关联.
- 需要进一步的研究来阐明连接FMF和ADHD的潜在生物机制.
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