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在COVID-19流行病中的多药和药物相互作用
Ricardo Enrique Barcia1,2, Guillermo Alberto Keller3, Natalia Bello4
16° Cátedra de Medicina Interna, Hospital de Clínicas "José de San Martín", Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. ricardoebarcia@hotmail.com.
Prague medical report
|December 9, 2023
概括
与非COVID-19病例相比,COVID-19住院治疗涉及的药物较少,多种药物较少,潜在药物相互作用 (P-DDI) 也较少. 可检测到的COVID-19患者在疫情期间死亡率更高.
科学领域:
- 卫生系统研究 卫生系统研究
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- COVID-19 流行病在全球范围内对医疗保健系统产生了重大影响.
- 了解住院患者的药物使用和相互作用对于患者的安全至关重要.
- 疫情的第一波疫情给患者护理管理带来了独特的挑战.
研究的目的:
- 为了比较COVID-19和非COVID-19住院期间的药物使用,多药和潜在的药物相互作用 (P-DDIs).
- 分析与COVID-19检测能力相关的死亡率.
- 评估大流行对急性护理机构处方模式的影响.
主要方法:
- 对1623例住院病人的回顾性分析 (2020年4月至9月).
- 将18岁以上的患者纳入COVID-19和非COVID-19病房.
- 利用计算机化系统 (SIMDA,Hdc.DrApp.la) 进行处方数据和P-DDI评估;COVID-19患者通过RT-PCR结果进行分类.
主要成果:
- 与非COVID-19患者 (p<0.001) 相比,COVID-19患者在第一天 (4.54对5.92) 和整个住院期间 (5.57对9.17) 接受的药物较少 (p<0.001).
- 多药性 (45%vs. 62%) 和过度多药性 (7%vs. 14%) 在COVID-19患者中明显较低 (p<0.001).
- 在COVID-19患者中观察到较少的P-DDI (0.31对0.40,p=0.022). 可检测到的COVID-19患者的死亡率更高 (19%vs. 9%).
结论:
- 与非COVID-19入院相比,COVID-19的住院治疗与减少药物使用,多药和P-DDI有关.
- 在可检测到病毒的COVID-19患者中观察到较高的死亡率.
- 这些发现凸显了COVID-19和大流行期间其他疾病之间的治疗强度和潜在风险差异.
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