有COVID-19的孕妇和胎儿血管发生症
Alla V Boychuk1, Yuliia B Yakymchuk1, Oksana О Shevchuk1
1I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
|December 9, 2023
概括
COVID-19对胎盘血管发生有负面影响,影响血管内皮生长因子A (VEGFA) 和胎盘生长因子 (PlGF). 胎儿后COVID-19综合征需要进一步研究和及时诊断相关疾病.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕期间的COVID-19感染对母亲和胎儿都有风险.
- 了解SARS-CoV-2对胎盘功能的影响对于管理怀孕结果至关重要.
- 胎盘血管生成在胎儿发育中起着至关重要的作用,并可能受到病毒感染的影响.
研究的目的:
- 分析COVID-19对怀孕和胎儿健康的临床和实验室影响.
- 为了研究COVID-19对胎盘血管生成标记物的影响.
- 为了评估胎儿后COVID-19综合征的潜在发展.
主要方法:
- 追溯和前性队列研究涉及有和没有COVID-19的孕妇.
- 使用超声波和心脏图谱评估胎儿状态.
- 对胎盘血管生成标记物的实验室分析:血管内皮生长因子A (VEGFA),胎盘生长因子 (PlGF) 和介素-32-alpha.
主要成果:
- 怀孕期间的COVID-19感染与VEGFA,Plgf和interleukin-32-alpha的度变化有关.
- 随着晚期妊娠COVID-19诊断,VEGFA水平显著增加,而PlGF水平下降.
- 干白素-32-α度在COVID-19的母亲中显著增加,特别是在妊娠的第三季度.
结论:
- COVID-19对胎盘血管生成产生不利影响,由VEGFA和PlGF水平的变化表明.
- 胎儿后COVID-19综合征是一种潜在的并发症,需要进一步调查和诊断方法.
- 后COVID-19综合征似乎是一种免疫介导的疾病,其特点是孕妇中长时间的细胞因子激活.
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